Active Ingredient: Isotretinoin
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Occasionally this flare-up is severe, necessitating oral antiobiotics such as erythromycin.
Some dermatologists favour a few weeks of pre-treatment with oral antibiotics before commencing isotretinoin to reduce the chance of a severe flare. Isotretinoin use can rarely lead to a more severe form of acne, acne fulminans. Teratogenicity Isotretinoin is a teratogen highly likely to cause birth defects if taken by women during pregnancy or even a short time before conception.
A few of the more common birth defects this drug can cause are hearing and visual impairment, missing or malformed earlobes, facial dysmorphism, and abnormalities in brain function.
About 160 babies with birth defects were born. After the FDA put the more strict iPLEDGE program in place for the companies marketing the drug in the US, in, 155 pregnancies occurred among 129,544 women of childbearing potential taking isotrentinoin 0.
Very rare effects include abnormal behaviour, psychosis, suicidal ideation, suicide attempts and suicide.
Beginning in 1983, isolated case reports emerged suggesting mood change, particularly depression, occurring during or soon after isotretinoin use. Psychosis Isotretinoin has also been linked to psychosis. Myalgia muscular pain and arthralgia joint pain are rare side effects.
Much more than the familiar blackheads, the condition is marked by tremendous pus filled lesions which typically spread across the entire face and neck leaving behind pitted scars.
One FDA official noted that the cysts can be so "cosmetically crippling that people cannot get jobs. I am now confident, happy and very excited about life.
I no longer feel inferior and can actually look people in the eyes. About 12 million people worldwide including 5 million Americans have taken Accutane, which is called Roaccutane outside the United States.
Accutane is an extremely dangerous teratogen: it can cause severe birth defects when taken during pregnancy.
About one quarter of babies born who have been exposed to Accutane during gestation have major congenital deformities.
Those babies born without major malformations frequently develop severe learning disabilities. Edward Lammer, a medical geneticist and consultant to FDA, describes the overall risk posed by Accutane: This is an extraordinarily high absolute risk, really comparable, in terms of environmental exposures, only to Thalidomide or certain congenital infections.
There is no other medication that poses an absolute risk anything remotely close to this, even medications used to treat cancer during pregnancy. Lammer, brain abnormalities are the most typical problem for Accutane babies, even babies who appear normal at birth i.
In addition, Accutane commonly inhibits the development of the bones and cartilage of the face. Heart defects, which often grow fatal, characterize the third most common problem described by Dr.