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Adverse effects The most common potential side effects when using tadalafil are headache, stomach discomfort or pain, indigestion, burping, acid reflux, back pain, muscle aches, flushing, and stuffy and runny nose.

These side effects reflect the ability of PDE 5 inhibition to cause vasodilation cause blood vessels to widen, and usually resolve after a few hours.

Back pain and muscle aches can occur 12 to 24 hours after taking the drug, and these symptoms usually resolve within 48 hours of onset. The FDA concluded that they were not able to draw a cause and effect relationship, only an association; the label of all three PDE 5 inhibitors was changed to alert clinicians to that fact.


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The presence of other drugs which induce this system can shorten tadalafil half-life and reduce serum levels, and hence efficacy, of the drug. Mechanism of action Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and the smooth muscle of the corpus cavernosum.


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This response is mediated by the release of nitric oxide NO from nerve terminals and endothelial cells, which stimulates the synthesis of cyclic guanosine monophosphate more commonly known as cyclic GMP or cGMP in smooth muscle cells.

Tadalafil and sildenafil and vardenafil inhibits PDE 5.

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