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Duplicates were removed through Endnote X 6, leaving 1687 results. Following the screening process, a total of 28 unique and relevant studies were reported in this systematic review see Additional file 3: Table S 2.
Seventeen studies were case reports or series, seven were non-randomised controlled trials, two were cohort studies, and two were cross-sectional studies.
Year and location This review looks at research on the treatment of sarcoptic mange in wildlife dating from the 1970 s.
Most studies were published following the year, although in several cases the research start date was many years earlier than this. Two studies treated greater than one species of wildlife and one of these studies, by Gakuya et al.
The most commonly studied families were the Bovidae and Canidae Fig.
Side effects included severely loose stools, profuse watery diarrhoea and death. Of the remaining 24 studies, only three studies specifically monitored for or stated an absence of deleterious side effects following treatments.
Adverse side effects were either absent or failed to be documented in the other studies.
Additional analyses Quality assessment using a decision tree left 15 studies suitable for further analysis.
This comprised of nine successful studies involving captive wildlife with a post-treatment monitoring period, five successful studies involving free-living wildlife with a post-treatment monitoring period, and one successful study describing the treatment of both captive and non-captive wildlife.
This study was subsequently included in both of these analysis groups; hence the cumulative number of studies under the captive and free-ranging treatment group headings in Fig.
There was no consensus between the severity of infection and the therapeutic dose of ivermectin delivered. Dose did not appear to affect the overall success of treatment i.
For instance, in a study by Leon-Vizcaino et al.