Active Ingredient: Azithromycin
Outcome assessment. A rectal swab specimen was obtained from each participant and cultured on days 7, 30, 60, and 90.
Each participant was interviewed by a research assistant at each visit for medication and also at the first posttreatment visit day 7 concerning side effects associated with the drug and any illnesses.
Statistical methods. The sample size needed for each group was 87.
All P values were 2-tailed. A total of 285 NTS carriers were eligible to participate in the trial; 4 each had NTS isolates of 2 different serotypes.
Twenty participants did not complete the 5-day study regimens absence from work, for 15 participants; subject quit job, for 4; and intolerability of side effects of norfloxacin, for 1.
As a consequence, the numbers of trial participants on assessment days 7, 30, 60, and 90 were 257, 244, 239, and 230, respectively. There were no statistically significant differences between the 3 treatment groups with regard to baseline characteristics table 1.
The bacteriological findings serotype distribution and antimicrobial susceptibility pattern of NTS isolates from pretreatment cultures, as well as proportions of participants with coinfection were comparable among the 3 treatment groups.
The Salmonella isolates recovered from the participants at enrollment were of 42 serotypes, the 2 most common of which were Salmonella enterica serotype Anatum and S.
Table 1 Baseline characteristics of participants in a trial of norfloxacin and azithromycin for treatment of nontyphoidal salmonellae carriage, according to treatment group.
Table 2 Bacteriological findings of pretreatment rectal swab cultures for the 3 treatment groups. Table 2 Open in new tab Download slide Bacteriological findings of pretreatment rectal swab cultures for the 3 treatment groups.
The results of cultures of rectal swabs obtained from the participants on assessment days 7, 30, 60, and 90 are shown in table 3.
Table 3 Proportions of trial participants with positive results of nontyphoidal Salmonella cultures, by treatment group, on each of the 5 bacteriological assessment days. Search Menu Abstract There has been inadequate was evaluated using 2 five-day regimens norfloxacin, 400 mg twice per day, and azithromycin.
In a randomized, placebo-controlled trial, such efficacy evaluation of an antibiotic for eradication of nontyphoidal salmonellae NTS in asymptomatic carriers.